The early-afternoon shooting apparently stemmed from an argument between two men. At least one of the men was armed and at least one had a student ID.
Both were wounded by gunfire and treated at a hospital, where they were detained.
"We haven't determined their exact involvement," said Capt. Ken Melancon.
Late Tuesday night, authorities said 22-year-old Carlton Berry was a shooter. Berry, who remained hospitalized, has been charged with aggravated assault.
A maintenance worker also was shot. He was struck in the leg and was in stable condition, said Richard Carpenter, chancellor of the Lone Star College System.
The shooting took place outside, between the academic building and the library, he said.
A possible fourth victim, a woman with a student ID who was either at or near the shooting, was treated at a hospital for medical problems. According to a federal law enforcement official who received reports from the scene, the fourth person suffered a heart attack.
The Lone Star College System is the largest institution of higher education in the Houston area, and the fastest-growing community college system in Texas, according to its website.
There were more than 10,000 students on the campus at the time of the shooting, said Jed Young, a school spokesman. The campus was evacuated and closed for the remainder of Tuesday.
The campus will reopen Wednesday.
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